Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for PRKCA (gene)


Gene Symbol:
PRKCA Homo sapiens Homo sapiens
Full name:
protein kinase C, alpha
Synonyms:
PRKACA, protein kinase C alpha type, protein kinase C, alpha, PKC-A, PKC-alpha, PKCA, MGC129900, MGC129901, aging-associated gene 6, AAG6
Genomic Location:
Chr 17: 61729388-62237324
Description:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for ph...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Danio rerio Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q22-q23.2


Transcripts Names
NM_002737



GO Molecular Function

histone threonine kinase activity | calcium-dependent protein kinase activity | cation binding | enzyme binding | ribonucleotide binding | nucleotide binding | protein serine/threonine kinase activity | protein kinase C activity | binding | catalytic activity | ATP binding | adenyl nucleotide binding | calcium-dependent protein serine/threonine kinase activity | purine nucleotide binding | calcium-dependent protein kinase C activity | ion binding | organic cyclic compound binding | nucleoside phosphate binding | purine ribonucleoside triphosphate binding | protein binding | zinc ion binding | histone kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | transition metal ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | kinase activity | histone kinase activity (H3-T6 specific) | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

positive regulation of cyclase activity | RNA metabolic process | positive regulation of smooth muscle cell proliferation | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | cell morphogenesis | regulation of muscle system process | regulation of biological process | negative regulation of multicellular organismal process | negative regulation of cellular response to insulin stimulus | positive regulation of locomotion | negative regulation of MAPK cascade | histone threonine kinase activity | positive regulation of behavior | response to cytokine stimulus | response to interleukin-1 | positive regulation of cellular component organization | cell motility | neuron projection morphogenesis | regulation of dense core granule biogenesis | regulation of cellular localization | positive regulation of lyase activity | intracellular signal transduction | regulation of synapse assembly | regulation of multi-organism process | positive regulation of apoptotic process | regulation of localization | induction of positive chemotaxis | regulation of biosynthetic process | positive regulation of cell communication | regulation of programmed cell death | positive regulation of cAMP biosynthetic process | peptidyl-amino acid modification | nucleic acid metabolic process | response to hormone stimulus | regulation of immune system process | positive regulation of muscle hypertrophy | regulation of biological quality | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | regulation of MAP kinase activity | histone modification | cell differentiation | positive regulation of epithelial cell proliferation | cellular macromolecule metabolic process | nervous system development | generation of precursor metabolites and energy | negative regulation of protein phosphorylation | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of protein modification process | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | regulation of peptide hormone secretion | calcium-dependent protein kinase activity | generation of neurons | response to antibiotic | blood vessel morphogenesis | multicellular organismal signaling | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | death | regulation of glucose import | regulation of cell motility | central nervous system neuron axonogenesis | localization | cellular homeostasis | cell projection morphogenesis | chromatin organization | regulation of defense response | negative regulation of signaling | synaptic transmission | neuron development | central nervous system neuron differentiation | response to estradiol stimulus | regulation of platelet aggregation | hemostasis | regulation of chemotaxis | negative regulation of apoptotic process | negative regulation of phosphorus metabolic process | response to corticosterone stimulus | regulation of cell cycle | response to growth factor stimulus | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | response to inorganic substance | activation of phospholipase C activity | negative regulation of cellular metabolic process | response to peptide hormone stimulus | regulation of behavior | tissue development | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | regulation of system process | positive regulation of cyclic nucleotide metabolic process | cell junction assembly | regulation of lyase activity | regulation of platelet activation | regulation of angiogenesis | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | regulation of metabolic process | inactivation of MAPK activity | epidermal growth factor receptor signaling pathway | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | regulation of response to stress | cellular aromatic compound metabolic process | cellular component organization | negative regulation of nucleotide metabolic process | calcium ion homeostasis | regulation of peptide secretion | negative regulation of transferase activity | negative regulation of protein modification process | negative regulation of purine nucleotide biosynthetic process | regulation of vasculature development | negative regulation of lyase activity | response to stimulus | peptidyl-threonine phosphorylation | negative regulation of cell communication | vasculature development | cell morphogenesis involved in neuron differentiation | response to chemical stimulus | cellular response to fibroblast growth factor stimulus | negative regulation of cAMP biosynthetic process | neutrophil chemotaxis | regulation of peptidyl-tyrosine phosphorylation | regulation of insulin secretion | positive regulation of protein metabolic process | response to stress | regulation of macromolecule biosynthetic process | negative regulation of protein kinase activity | posttranscriptional regulation of gene expression | regulation of cell proliferation | regulation of nucleotide biosynthetic process | positive regulation of nucleobase-containing compound metabolic process | regulation of response to external stimulus | negative regulation of glucose transport | regulation of anatomical structure morphogenesis | protein serine/threonine kinase activity | programmed cell death | protein kinase C activity | response to alcohol | cardiovascular system development | cellular nitrogen compound metabolic process | positive regulation of lipase activity | negative regulation of transport | positive regulation of blood vessel endothelial cell migration | ERBB signaling pathway | response to endogenous stimulus | negative regulation of metabolic process | cellular component assembly | regulation of wound healing | protein modification process | regulation of cAMP metabolic process | mRNA metabolic process | cartilage development | regulation of synapse structure and activity | regulation of peptide transport | regulation of cell adhesion | negative regulation of purine nucleotide metabolic process | macromolecule modification | cell-cell signaling | peptidyl-threonine modification | cell chemotaxis | catalytic activity | metal ion homeostasis | blood vessel development | response to ethanol | leukocyte migration | positive regulation of macrophage differentiation | blood coagulation | positive regulation of exocytosis | locomotion | positive regulation of phospholipase C activity | central nervous system neuron development | apoptotic process | system development | chondrocyte differentiation | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organismal development | negative regulation of catalytic activity | cell migration | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | learning or memory | taxis | positive regulation of multicellular organismal process | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | negative regulation of glucose import | regulation of phosphorylation | fibroblast growth factor receptor signaling pathway | regulation of hormone secretion | positive regulation of purine nucleotide metabolic process | wound healing | regulation of receptor-mediated endocytosis | response to abiotic stimulus | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | positive regulation of chemotaxis | platelet activation | cellular component biogenesis | positive regulation of secretion | neurological system process | histone-threonine phosphorylation | positive regulation of dense core granule biogenesis | desmosome assembly | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of multicellular organismal development | cellular ion homeostasis | regulation of macromolecule metabolic process | regulation of blood coagulation | regulation of transferase activity | calcium-dependent protein serine/threonine kinase activity | regulation of synapse organization | regulation of nitrogen compound metabolic process | single-organism process | regulation of cyclic nucleotide biosynthetic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of nucleotide biosynthetic process | small molecule metabolic process | negative regulation of insulin receptor signaling pathway | negative regulation of nitrogen compound metabolic process | positive regulation of intracellular protein kinase cascade | negative regulation of protein serine/threonine kinase activity | response to corticosteroid stimulus | regulation of cellular component movement | response to oxidative stress | regulation of the force of heart contraction | axonogenesis | positive regulation of hydrolase activity | regulation of glial cell apoptotic process | positive regulation of cell differentiation | regulation of endothelial cell migration | positive regulation of myeloid cell differentiation | cognition | positive regulation of adenylate cyclase activity | positive regulation of cell migration | chromatin modification | regulation of coagulation | negative regulation of nucleotide biosynthetic process | biological regulation | calcium-dependent protein kinase C activity | regulation of primary metabolic process | negative regulation of cyclic nucleotide biosynthetic process | cellular component movement | regulation of cellular protein metabolic process | histone H3-T6 phosphorylation | angiogenesis | positive regulation of response to external stimulus | phosphorylation | negative regulation of adenylate cyclase activity | regulation of phospholipase activity | positive regulation of cyclic nucleotide biosynthetic process | positive regulation of macromolecule metabolic process | response to toxin | regulation of cyclase activity | induction of apoptosis by extracellular signals | regulation of heart contraction | negative regulation of cAMP metabolic process | protein phosphorylation | cell morphogenesis involved in differentiation | cation homeostasis | positive regulation of biological process | phosphate-containing compound metabolic process | regulation of purine nucleotide metabolic process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | positive regulation of phosphorus metabolic process | response to estrogen stimulus | negative regulation of nucleobase-containing compound metabolic process | regulation of nucleotide metabolic process | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | induction of programmed cell death | positive regulation of defense response | regulation of cAMP biosynthetic process | regulation of hemostasis | regulation of protein metabolic process | system process | positive regulation of signal transduction | positive regulation of biosynthetic process | leukocyte chemotaxis | desmosome organization | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | positive regulation of nervous system development | regulation of locomotion | negative regulation of MAP kinase activity | histone phosphorylation | positive regulation of synapse assembly | positive regulation of transport | regulation of purine nucleotide biosynthetic process | coagulation | regulation of mitotic cell cycle | regulation of phospholipase C activity | positive regulation of molecular function | neuron differentiation | positive regulation of purine nucleotide biosynthetic process | cellular component organization at cellular level | activation of adenylate cyclase activity | protein metabolic process | regulation of cardiac muscle hypertrophy | positive regulation of protein modification process | response to organic substance | regulation of homotypic cell-cell adhesion | nerve growth factor receptor signaling pathway | histone kinase activity | cellular developmental process | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | regulation of kinase activity | response to wounding | regulation of lipopolysaccharide-mediated signaling pathway | response to mechanical stimulus | regulation of intracellular protein kinase cascade | negative regulation of intracellular protein kinase cascade | regulation of exocytosis | anatomical structure development | regulation of positive chemotaxis | regulation of multicellular organismal process | cell surface receptor signaling pathway | cell projection organization | metabolic process | transferase activity, transferring phosphorus-containing groups | primary metabolic process | cell-cell junction assembly | response to mineralocorticoid stimulus | regulation of body fluid levels | oxidation-reduction process | negative regulation of programmed cell death | positive regulation of lipopolysaccharide-mediated signaling pathway | cellular response to carbohydrate stimulus | phosphotransferase activity, alcohol group as acceptor | negative regulation of heart contraction | regulation of vesicle-mediated transport | chemical homeostasis | regulation of secretion | behavior | positive regulation of cell death | cell adhesion | cellular response to stimulus | nucleobase-containing compound metabolic process | protein kinase activity | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | regulation of hydrolase activity | cellular component morphogenesis | connective tissue development | induction of apoptosis | cell death | negative regulation of biosynthetic process | regulation of glucose transport | organ development | response to reactive oxygen species | regulation of endothelial cell proliferation | regulation of insulin receptor signaling pathway | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | cellular response to endogenous stimulus | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | regulation of lipase activity | transferase activity | ion homeostasis | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | negative regulation of biological process | negative regulation of translation | positive regulation of response to biotic stimulus | positive regulation of phospholipase activity | positive regulation of endothelial cell migration | negative regulation of glial cell apoptotic process | cell activation | positive regulation of MAPK cascade | regulation of adenylate cyclase activity | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of molecular function | regulation of macrophage differentiation | negative regulation of signal transduction | signaling | covalent chromatin modification | response to organic cyclic compound | negative regulation of cyclase activity | negative regulation of macromolecule metabolic process | regulation of muscle adaptation | cell development | energy reserve metabolic process | regulation of endocytosis | single-organism behavior | regulation of molecular function | regulation of epithelial cell proliferation | regulation of muscle hypertrophy | cellular component organization or biogenesis at cellular level | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | positive regulation of response to stimulus | cellular divalent inorganic cation homeostasis | regulation of nervous system development | regulation of developmental process | energy derivation by oxidation of organic compounds | kinase activity | developmental process | response to external stimulus | organelle organization | localization of cell | peptidyl-serine phosphorylation | regulation of response to biotic stimulus | cellular protein modification process | positive regulation of nucleotide metabolic process | histone kinase activity (H3-T6 specific) | regulation of cyclic nucleotide metabolic process | negative regulation of cellular biosynthetic process | positive regulation of cellular process | regulation of transport | positive regulation of cAMP metabolic process | negative regulation of cell proliferation | peptidyl-serine modification | regulation of cell-cell adhesion | regulation of cellular component biogenesis | response to fibroblast growth factor stimulus | cellular metal ion homeostasis | single-multicellular organism process | single organism signaling | negative regulation of cyclic nucleotide metabolic process | heterocycle metabolic process | transmission of nerve impulse | central nervous system development | negative regulation of cellular macromolecule biosynthetic process | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | chromosome organization | cellular component assembly at cellular level | skeletal system development | positive regulation of myeloid leukocyte differentiation | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to carbohydrate stimulus | response to steroid hormone stimulus | regulation of translation | negative regulation of cell death | circulatory system development | regulation of inflammatory response | aging | chemotaxis | biological adhesion | divalent inorganic cation homeostasis | positive regulation of angiogenesis | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | response to glucocorticoid stimulus | cell junction organization | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | positive regulation of positive chemotaxis | regulation of phosphorus metabolic process

GO Cellular Component

nonmotile primary cilium | dendrite | intracellular membrane-bounded organelle | neuron projection | organelle membrane | cell body | cell | mitochondrial part | nuclear lumen | neuronal cell body | cytoplasm | intracellular organelle | endoplasmic reticulum | macromolecular complex | cell projection | nuclear part | nucleoplasm | plasma membrane | organelle part | intracellular organelle part | organelle lumen | cilium | membrane raft | photoreceptor outer segment | envelope | perinuclear region of cytoplasm | mitochondrion | organelle envelope | membrane part | cell part | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | cell periphery | cytoplasmic part | membrane-enclosed lumen | intracellular organelle lumen | mitochondrial membrane | cytosol | intracellular part | primary cilium | intracellular | membrane | protein complex