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QuickView for CD44 (gene)


Gene Symbol:
CD44 Homo sapiens Homo sapiens
Full name:
CD44 molecule (Indian blood group)
Synonyms:
MUTCH-I, Pgp1, phagocytic glycoprotein 1, phagocytic glycoprotein I, MIC4, MC56, MDU2, MDU3, MGC10468, CD44 antigen, CD44 antigen (homing function and Indian blood group system), CD44 molecule (Indian blood group), ECMR-III, CDW44, CDW44 antigen, cell adhesion molecule, cell surface glycoprotein CD44, CSPG8, chondroitin sulfate proteoglycan 8, AL133330.1, antigen gp90 homing receptor, GP90 lymphocyte homing/adhesion receptor, HCELL, hematopoietic cell E- and L-selectin ligand, heparan sulfate proteoglycan, Hermes antigen, epican, extracellular matrix receptor III, extracellular matrix receptor-III, LHR, IN, HUTCH-I, hyaluronate receptor, homing function and Indian blood group system
Genomic Location:
Chr 11: 35116993-35210525
Description:
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions i...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 11
11p13





GO Molecular Function

transmembrane signaling receptor activity | hyaluronic acid binding | hexosaminidase activity | hyalurononglucosaminidase activity | hydrolase activity | hydrolase activity, hydrolyzing O-glycosyl compounds | carbohydrate derivative binding | binding | catalytic activity | collagen binding | signaling receptor activity | hydrolase activity, acting on glycosyl bonds | receptor activity | molecular transducer activity | protein binding | signal transducer activity | glycosaminoglycan binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | regulation of biological process | regulation of cysteine-type endopeptidase activity | response to cytokine stimulus | developmental process involved in reproduction | cell-substrate adhesion | morphogenesis of an epithelium | positive regulation of cell communication | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | negative regulation of cysteine-type endopeptidase activity | negative regulation of cellular process | defense response | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of protein modification process | regulation of response to stimulus | cellular process | death | epithelial tube morphogenesis | regulation of DNA damage response, signal transduction by p53 class mediator | negative regulation of signaling | positive regulation of peptidyl-serine phosphorylation | reproductive system development | carbohydrate derivative catabolic process | positive regulation of heterotypic cell-cell adhesion | regulation of embryonic development | negative regulation of apoptotic process | branching involved in ureteric bud morphogenesis | glycosaminoglycan catabolic process | response to growth factor stimulus | transmembrane signaling receptor activity | cellular response to chemical stimulus | tissue development | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of monocyte aggregation | interferon-gamma-mediated signaling pathway | catabolic process | positive regulation of cellular protein metabolic process | regulation of response to stress | epithelium development | prostate gland epithelium morphogenesis | hexosaminidase activity | urogenital system development | cellular response to interferon-gamma | response to stimulus | negative regulation of cell communication | response to chemical stimulus | cellular response to fibroblast growth factor stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | leukocyte aggregation | gland morphogenesis | hyalurononglucosaminidase activity | hydrolase activity | response to stress | regulation of heterotypic cell-cell adhesion | hydrolase activity, hydrolyzing O-glycosyl compounds | tube morphogenesis | positive regulation of cell-cell adhesion | regulation of anatomical structure morphogenesis | programmed cell death | reproduction | response to endogenous stimulus | cartilage development | regulation of cell adhesion | catalytic activity | monocyte aggregation | regulation of cellular response to stress | apoptotic process | system development | reproductive process | regulation of signal transduction | ureteric bud development | Wnt receptor signaling pathway | multicellular organismal development | negative regulation of catalytic activity | regulation of peptidase activity | regulation of MAPK cascade | regulation of catalytic activity | regulation of phosphorylation | hyaluronan metabolic process | negative regulation of peptidase activity | wound healing | regulation of gene expression | aminoglycan catabolic process | branching involved in prostate gland morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of multicellular organismal development | organ morphogenesis | regulation of macromolecule metabolic process | signaling receptor activity | single-organism process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | cytokine-mediated signaling pathway | positive regulation of intracellular protein kinase cascade | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | cellular response to cytokine stimulus | biological regulation | regulation of primary metabolic process | hydrolase activity, acting on glycosyl bonds | regulation of cellular protein metabolic process | carbohydrate metabolic process | positive regulation of macromolecule metabolic process | positive regulation of biological process | negative regulation of response to stimulus | positive regulation of phosphorus metabolic process | cell communication | regulation of cellular metabolic process | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | wound healing involved in inflammatory response | ureteric bud morphogenesis | positive regulation of protein modification process | response to organic substance | gland development | regulation of homotypic cell-cell adhesion | tissue morphogenesis | branching morphogenesis of a tube | response to wounding | negative regulation of DNA damage response, signal transduction by p53 class mediator | positive regulation of monocyte aggregation | regulation of intracellular protein kinase cascade | anatomical structure development | regulation of multicellular organismal process | cell surface receptor signaling pathway | signal transducer activity | leukocyte cell-cell adhesion | metabolic process | primary metabolic process | negative regulation of programmed cell death | regulation of cell-cell adhesion involved in gastrulation | cell adhesion | regulation of response to DNA damage stimulus | immune response | cellular response to stimulus | single organism reproductive process | organic substance metabolic process | regulation of hydrolase activity | connective tissue development | cell death | organ development | cellular response to endogenous stimulus | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | prostate gland morphogenesis | negative regulation of biological process | cell-cell adhesion | response to interferon-gamma | positive regulation of MAPK cascade | morphogenesis of a branching epithelium | aminoglycan metabolic process | regulation of peptidyl-serine phosphorylation | anatomical structure formation involved in morphogenesis | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | cell-matrix adhesion | regulation of molecular function | positive regulation of phosphorylation | morphogenesis of a branching structure | anatomical structure morphogenesis | prostate gland development | regulation of endopeptidase activity | positive regulation of response to stimulus | positive regulation of homotypic cell-cell adhesion | reproductive structure development | regulation of developmental process | developmental process | positive regulation of cellular process | tube development | regulation of gastrulation | carbohydrate derivative metabolic process | regulation of cell-cell adhesion | innate immune response | response to fibroblast growth factor stimulus | single-multicellular organism process | single organism signaling | negative regulation of hydrolase activity | negative regulation of response to DNA damage stimulus | positive regulation of metabolic process | skeletal system development | immune system process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | biological adhesion | homotypic cell-cell adhesion | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | hyaluronan catabolic process | positive regulation of gene expression | cellular response to growth factor stimulus | glycosaminoglycan metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral to membrane | plasma membrane part | cell | intrinsic to membrane | external side of plasma membrane | plasma membrane | membrane part | integral to plasma membrane | cell part | cell periphery | basolateral plasma membrane | cell surface | membrane | intrinsic to plasma membrane