Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Imuthiol (sodium-diethyl-dithiocarbamate, DTC) has been proven to possess immunomodulatory properties, this effect, however, varies in different model systems. This study was performed to assess the possible effect of imuthiol on etoposide-induced apoptosis in the human promyelocytic leukemia cell line, HL-60. In vitro pre-treatment with imuthiol at concentrations between 50 and 100 microM significantly inhibited etoposide-induced apoptosis of HL-60 cells, the inhibition appeared to be dose dependent. This effect may be associated with the immunomodulatory activity of imuthiol.

Citation

E Nagy, J Szakonyi, P Gergely. Imuthiol inhibits the etoposide-induced apoptosis in HL-60 cells. Immunology letters. 1998 Nov;64(1):1-4

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 9865594

View Full Text