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The inhibitor of chloride channels DIDS (10 microM) decreased and a chloride-free medium increased the cAMP level in the Xenopus laevis follicles stimulated by human chorionic gonadotropin. Also, DIDS inhibited while the chloride-free medium stimulated maturation of the follicle-enclosed oocytes.


M N Skoblina, I Khukhtaniemi. Effect of a chloride channel inhibitor and chloride-free medium on choriogonin-induced cAMP formation by Xenopus laevis follicles]. Ontogenez. 1998 May-Jun;29(3):178-80

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PMID: 9702794

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