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13-Tert-butoxycarbonylhydrazone of rubomycin was prepared on interaction of rubomycin with tert-butoxycarbonylhydrazine. The new compound showed a high antitumor activity with respect to lymphosarcoma LIO-1 and Garding-Passey melanoma. The compound had no advantages over the initial rubomycin in the treatment of these tumors, was inferior to rubomycin with respect to its activity against leukemia P-388 and unlike rubomycin had practically no effect on leukemia L-1210.


L S Povarov, L E Gol'dberg, V S Bazhanov, E N Olsuf'eva, L A Averbukh. Synthesis of rubomycin 13-tert-butoxycarbonylhydrazone and the study of its antitumor action]. Antibiotiki. 1981 Nov;26(11):813-6

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PMID: 6895688

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