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IL-6-STAT3 axis is known as a key factor of tumor progression. In this issue of Immunity, Yu and colleagues (2016) show that IL-6-binding CD5, rather than IL-6 receptor-α in B cells, amplifies STAT3 activation via JAK-STAT signaling to promote cancer. Copyright © 2016 Elsevier Inc. All rights reserved.


Kazuya Masuda, Tadamitsu Kishimoto. CD5: A New Partner for IL-6. Immunity. 2016 Apr 19;44(4):720-2

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PMID: 27096313

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