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    The process of degradation was studied by using an HPLC-DAD method. Two degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The influence of temperature and relative air humidity (RH) on the stability of cefoselis sulfate was investigated. In the solid state at increased RH the degradation of cefoselis sulfate was an autocatalytic reaction of the first order with respect to substrate concentration while in dry air was first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of degradation were calculated. Copyright © 2015 Elsevier B.V. All rights reserved.


    Przemysław Zalewski, Robert Skibiński, Alicja Talaczyńska, Magdalena Paczkowska, Piotr Garbacki, Judyta Cielecka-Piontek. Stability studies of cefoselis sulfate in the solid state. Journal of pharmaceutical and biomedical analysis. 2015 Oct 10;114:222-6

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    PMID: 26073113

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