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Evaluation of SM-4300, a new intact gammaglobulin for peritoneal use, about antimicrobial titers and prophylactic effects on bacterial infections in mice was performed. The results are as follows: The antimicrobial titers of SM-4300 against bacteria, protozoa, and virus were almost the same as those of venoglobulin-I, another intact gammaglobulin. The difference in antimicrobial titers among several lots of SM-4300 was unrecognizable. Prophylactic effects of SM-4300 on systemic infections in granulocytopenic mice were remarkable and were comparable to those of venoglobulin-I. About 9% of venoglobulin-I treated mice died within 24 hours after the injection. On the contrary, no mice died by SM-4300 treatment.


M Kato, K Kadota, T Okuda. Evaluation of SM-4300, a new intact gammaglobulin, with venoglobulin-I]. The Japanese journal of antibiotics. 1985 Sep;38(9):2688-97

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PMID: 2416962

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