Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Many recombinant growth factors have failed in clinical trials due to off-target effects. We describe a method for circumventing off-target effects that involves equipping cells with a conditionally active signaling protein that can be specifically activated by an exogenously administered synthetic ligand. We believe that this approach will have many applications in gene and cell therapy.

Citation

C P Miller, C A Blau. Using gene transfer to circumvent off-target effects. Gene therapy. 2008 May;15(10):759-64

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 18356813

View Full Text