Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Unsymmetrical bifunctional antitumor agent WMC79 was further optimized to generate compound 7b that not only inhibited the growth of many tumor cell lines, but caused rapid apoptosis. Unlike the parent compound, 7b is toxic to both p53 positive and negative cancer cells. It has potent in vivo activity against xenografts of human colon and pancreatic tumors in athymic mice.


Humcha K Hariprakasha, Teresa Kosakowska-Cholody, Colin Meyer, Wieslaw M Cholody, Sherman F Stinson, Nadya I Tarasova, Christopher J Michejda. Optimization of naphthalimide-imidazoacridone with potent antitumor activity leading to clinical candidate (HKH40A, RTA 502). Journal of medicinal chemistry. 2007 Nov 15;50(23):5557-60

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 17939651

View Full Text