Clear Search sequence regions


We evaluated the antiemetic effect of zacopride, a potent 5-HT3-receptor antagonist with 5-HT4-receptor agonist properties, on delayed emesis caused by cisplatin (5 mg/kg, i.p.) in ferrets, compared with granisetron, a selective 5-HT3-receptor antagonist. Multiple intravenous injections of zacopride at 1 mg/kg, a dose that completely inhibited acute emesis caused bycisplatin (10 mg/kg, i.v.), significantly reduced delayed emesis. Granisetron (3.2 mg/kg) also reduced delayed emesis but this failed to reach statistical significance. The present study suggests that a combined 5-HT3-receptor antagonist/5-HT4-receptor agonist, like zacopride, may be useful against both acute and delayed emesis induced by cancer chemotherapy.

Citation

Hisashi Yamakuni, Hiroe Nakayama, Shigeo Matsui, Katsunori Imazumi, Masahiko Matsuo, Seitaro Mutoh. Inhibitory effect of zacopride on Cisplatin-induced delayed emesis in ferrets. Journal of pharmacological sciences. 2006 May;101(1):99-102

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 16651699

View Full Text